| Date | Mar 12 | Total matches | 4 | 
| Men's matches | 3 | Women's matches | 1 | 
| Singles matches | 2 | Tag Team matches | 1 | 
This episode of SmackDown took place on March 12, 2021 and featured 4 matches on the card. A majority of the matches ended by pinfall, submission, or the rules stipulated by the match, but 1 of the 4 matches ended with a non-finish disqualification or count-out. Only one championship, the Intercontinental Championship, was defended on the card.
The matches featured 16 wrestlers and 2 tag teams, highlighted by Big E, Natalya, Tamina, Cesaro, Rey Mysterio, Angelo Dawkins, Montez Ford and Dominik Mysterio.
| Men's Singles  | 
| 5-1 (Overall: 8-1, Last 5: 5-0) Champion | 
| 0-6 (Overall: 1-11, Last 5: 0-5) | 
| Women's Tag Team | 
| 2-1 (Last 5: 2-1) | 
| 0-3 (Last 5: 0-4) | 
| Men's Singles | 
| 5-1 (Overall: 7-5, Last 5: 4-1) | 
| 0-2 (Overall: 0-2, Last 5: 2-3) | 
| Match ended by Disqualification | 
| Men's Four on Four Tag Team |